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		<title>OmegaVit For Dogs</title>
		<link>https://formule-art.com/product/omegavit-for-dogs/</link>
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		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Tue, 03 Dec 2024 08:07:39 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2697</guid>

					<description><![CDATA[<h1>"OmegaVit for Dogs – Tail-Wagging Wellness in Every Drop!"</h1>]]></description>
										<content:encoded><![CDATA[<h1>OmegaVit For Dogs</h1>
<p>&nbsp;</p>
<p>Support your dog’s active and joyful life with <em>OmegaVit for Dogs</em>. Designed with 1600 mg of pure, sustainably sourced Omega-3 from Lysi Iceland and fortified with Vitamins D3, E, and A from DSM Switzerland, this advanced formula targets your dog’s unique physiological needs. Crafted by <em>Formule Art Germany</em> and trusted by the <em>PetField</em> brand, <em>OmegaVit for Dogs</em> promotes heart, joint, and cognitive health, ensuring your loyal companion stays energetic and healthy for years to come.</p>
<h4><strong>Product Indications</strong></h4>
<p><em>OmegaVit for Dogs</em> is recommended for:</p>
<ul>
<li><strong>Heart Health</strong>: Supports cardiovascular function and promotes a strong, healthy heart.</li>
<li><strong>Joint and Mobility Support</strong>: Reduces inflammation, enhancing flexibility and ease of movement.</li>
<li><strong>Cognitive Function</strong>: Boosts focus, memory, and learning abilities, especially in aging dogs.</li>
<li><strong>Skin and Coat Care</strong>: Reduces dryness and promotes a shiny, resilient coat.</li>
<li><strong>Immune System Strength</strong>: Fortifies natural defenses to help your dog resist illnesses.</li>
</ul>
<h4><strong>How to Use</strong></h4>
<ol>
<li>
<ol>
<li>Shake the bottle well before use.</li>
<li>Administer directly or mix into your dog’s food:
<ul>
<li><strong>Dosage</strong>: 1 pump per 2.5 kg of body weight. Each pump dispenses approximately 1.8 cc.</li>
</ul>
</li>
<li>Provide fresh water at all times for your dog.</li>
</ol>
</li>
</ol>
<h4><strong>Required Considerations</strong></h4>
<ul>
<li>Use as a supplement, not a sole source of nutrition.</li>
<li>Consult your veterinarian for the correct dosage, particularly for pregnant or health-compromised dogs.</li>
<li>Store in a cool, dry place, away from direct sunlight.</li>
<li>Keep out of reach of children and other animals.</li>
</ul>
<h4><strong>Ingredient Actions</strong></h4>
<ul>
<li><strong>Omega-3 (1600 mg)</strong>: Sustainably sourced fish oil supports heart health, joint mobility, and cognitive sharpness.</li>
<li><strong>Vitamin D3</strong>: Essential for strong bones and teeth, supporting your dog’s active lifestyle.</li>
<li><strong>Vitamin E</strong>: Protects cells and nourishes skin for a healthy, glossy coat.</li>
<li><strong>Vitamin A</strong>: Enhances vision, immune response, and overall health.</li>
</ul>
<p>&nbsp;</p>
]]></content:encoded>
					
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			</item>
		<item>
		<title>OmegaVit for Cats</title>
		<link>https://formule-art.com/product/omegavit-for-cats/</link>
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		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Tue, 03 Dec 2024 08:02:45 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2694</guid>

					<description><![CDATA[<h2>"OmegaVit for Cats – Purring with Health and Happiness!"</h2>]]></description>
										<content:encoded><![CDATA[<h1>OmegaVit For Cats</h1>
<p>&nbsp;</p>
<p>Treat your feline friend to the best in nutritional care with <em>OmegaVit for Cats</em>. Specially formulated with 1000 mg of pure Omega-3 sourced from sustainable fisheries by Lysi Iceland and enriched with Vitamins D3, E, and A from DSM Switzerland, this advanced supplement promotes optimal health and vitality. Exclusively crafted by <em>Formule Art Germany</em> and trusted by the <em>PetField</em> brand, <em>OmegaVit for Cats</em> supports your cat’s unique physiological needs, ensuring a healthier, happier life.</p>
<p><em>OmegaVit for Cats</em> is recommended for:</p>
<ul>
<li><strong>Skin and Coat Health</strong>: Reduces dryness and irritation while promoting a glossy, soft coat.</li>
<li><strong>Cognitive Support</strong>: Enhances mental sharpness, learning, and memory in cats of all ages.</li>
<li><strong>Joint Health</strong>: Aids in mobility and flexibility, especially beneficial for aging or less active cats.</li>
<li><strong>Immune System Boost</strong>: Strengthens your cat&#8217;s natural defenses to help combat illnesses.</li>
<li><strong>Vision Care</strong>: Supports eye health and optimal vision with Vitamin A.</li>
</ul>
<h3><strong>How to Use</strong></h3>
<h4><strong>OmegaVit for Cats</strong></h4>
<ol>
<li>Shake the bottle well before use.</li>
<li>Administer directly or mix into your cat&#8217;s food:
<ul>
<li><strong>Dosage</strong>: 1 pump per 2 kg of body weight. Each pump dispenses approximately 1.8 cc.</li>
</ul>
</li>
<li>Ensure your cat has access to fresh water at all times.</li>
</ol>
<h4><strong>Required Considerations</strong></h4>
<ul>
<li>This is a supplemental product and not a replacement for balanced cat food.</li>
<li>Consult your veterinarian for the appropriate dosage, especially for pregnant or health-compromised cats.</li>
<li>Store in a cool, dry place, away from direct sunlight.</li>
<li>Keep out of reach of children and other animals.</li>
</ul>
<h4><strong>Ingredient Actions</strong></h4>
<ul>
<li><strong>Omega-3 (1000 mg)</strong>: Sustainably sourced fish oil supports skin health, joint flexibility, and cognitive function.</li>
<li><strong>Vitamin D3</strong>: Enhances calcium absorption, supporting bone and dental health.</li>
<li><strong>Vitamin E</strong>: A natural antioxidant that nourishes the skin and protects cells.</li>
<li><strong>Vitamin A</strong>: Vital for vision, immune health, and overall well-being.</li>
</ul>
<p>&nbsp;</p>
]]></content:encoded>
					
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			</item>
		<item>
		<title>Benzoyl Peroxide 3% Shampoo</title>
		<link>https://formule-art.com/product/bpo/</link>
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		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Thu, 06 Jun 2024 08:30:38 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2635</guid>

					<description><![CDATA[<h1>"<strong>Gentle Care, Healthier Skin – Because Your Pet Deserves the Best!</strong>"</h1>]]></description>
										<content:encoded><![CDATA[<h1>Benzoyl Peroxide 3% Shampoo</h1>
<h3><strong>Product Description</strong></h3>
<p>Transform your pet’s grooming routine with <em>Benzoyl 3%</em>, a veterinary shampoo that combines advanced care with pet-friendly gentleness. Formulated with 3% Benzoyl Peroxide and enriched with premium Vitamin E from DSM Switzerland, this cruelty-free and SLS-free shampoo is tailored to meet the sensitive needs of pets. Perfect for combating fungal issues while nourishing and soothing skin, <em>Benzoyl 3%</em> delivers effective cleansing and long-lasting skin health. Designed by the experts at <em>Formule Art</em> and trusted by the <em>PetField</em> brand, it’s the ultimate choice for pet parents who demand the best.</p>
<h3><strong>Ingredient Actions</strong></h3>
<ul>
<li><strong>Benzoyl Peroxide 3%</strong>: A proven antifungal and antibacterial agent that helps reduce oil production, unclogs pores, and eliminates harmful microorganisms, promoting healthy skin and coat.</li>
<li><strong>Vitamin E</strong>: An antioxidant powerhouse sourced from DSM Switzerland, it soothes inflammation, protects against free radicals, and enhances skin repair.</li>
</ul>
<h3><strong>Product Indications</strong></h3>
<p><em>Benzoyl 3%</em> is recommended for:</p>
<ul>
<li>Managing fungal skin conditions in pets.</li>
<li>Removing excess oil and debris from the skin and fur.</li>
<li>Supporting pets with mild to moderate skin irritations.</li>
<li>Enhancing skin hydration and elasticity.</li>
</ul>
<h3><strong>How to Use</strong></h3>
<ol>
<li>Wet your pet&#8217;s fur thoroughly with lukewarm water.</li>
<li>Apply an adequate amount of <em>Benzoyl 3%</em> shampoo and gently massage it into the fur and skin, focusing on the problem areas.</li>
<li>Leave the shampoo on for 5-10 minutes to allow full absorption.</li>
<li>Rinse thoroughly with water and towel dry your pet.</li>
<li>Use as directed by your veterinarian or as part of a regular grooming routine.</li>
</ol>
<h3><strong>Required Considerations</strong></h3>
<ul>
<li>For external use only. Avoid contact with the eyes and mucous membranes.</li>
<li>Do not use it on open wounds or severely irritated skin.</li>
<li>Consult a veterinarian if irritation persists or worsens.</li>
<li>Store in a cool, dry place, away from direct sunlight.</li>
</ul>
<p>&nbsp;</p>
]]></content:encoded>
					
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			</item>
		<item>
		<title>HexSpary</title>
		<link>https://formule-art.com/product/chxs/</link>
					<comments>https://formule-art.com/product/chxs/#respond</comments>
		
		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Tue, 30 Apr 2024 10:49:20 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2633</guid>

					<description><![CDATA[<h1>"Spray Away Infections – HexSpray for Happy, Healthy Skin!"</h1>]]></description>
										<content:encoded><![CDATA[<h2>HexSpray</h2>
<p>&nbsp;</p>
<h3><strong>Product Description</strong></h3>
<p>Say goodbye to stubborn skin infections with <em>HexSpray</em>, the convenient and effective solution for your pet&#8217;s skin health. Powered by Chlorhexidine, a trusted antimicrobial agent, and enriched with Vitamin E from DSM Switzerland, this spray provides fast relief and long-lasting protection against harmful microorganisms. Designed for ease of use and pet-friendly care, <em>HexSpray</em> is the perfect choice for targeting localized skin issues while promoting healthier, soothed skin. From the trusted <em>PetField</em> brand, this innovative formula ensures your pet feels their best every day.</p>
<h3><strong>Product Indications</strong></h3>
<p><em>HexSpray</em> is recommended for:</p>
<ul>
<li>Treating localized bacterial and fungal skin infections.</li>
<li>Supporting wound care and preventing infection.</li>
<li>Reducing skin irritation and inflammation.</li>
<li>Promoting skin repair and hydration.</li>
</ul>
<h3><strong>How to Use</strong></h3>
<ol>
<li>Clean and dry the affected area before application.</li>
<li>Hold the <em>HexSpray</em> bottle approximately 10 cm (4 inches) away from the skin.</li>
<li>Spray a light, even layer over the affected area.</li>
<li>Allow the spray to air dry; do not rinse off.</li>
<li>Repeat as directed by your veterinarian or 1-2 times daily for best results.</li>
</ol>
<h3><strong>Required Considerations</strong></h3>
<ul>
<li>For external use only. Avoid contact with eyes, nose, and mouth.</li>
<li>Do not apply on open, deep, or large wounds without veterinary guidance.</li>
<li>Consult a veterinarian if irritation persists or adverse reactions occur.</li>
<li>Keep out of reach of children and store in a cool, dry place.</li>
</ul>
<h3><strong>Ingredient Actions</strong></h3>
<ul>
<li><strong>Chlorhexidine</strong>: A broad-spectrum antimicrobial that effectively eliminates bacteria and fungi, helping to treat and prevent infections.</li>
<li><strong>Vitamin E</strong>: An antioxidant sourced from DSM Switzerland, it soothes and nourishes the skin, reducing irritation and promoting natural healing.</li>
</ul>
]]></content:encoded>
					
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			</item>
		<item>
		<title>KetoHex shampoo</title>
		<link>https://formule-art.com/product/kchx/</link>
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		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Tue, 30 Apr 2024 10:43:18 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2632</guid>

					<description><![CDATA[<h1>"Strong on Infections, Gentle on Pets – Choose KetoHex!"</h1>]]></description>
										<content:encoded><![CDATA[<h2><strong style="font-size: 16px;">KetoHex Shampoo</strong></h2>
<p>&nbsp;</p>
<h3><strong>Product Description</strong></h3>
<p>Give your pet the ultimate defense against skin issues with <em>KetoHex</em> shampoo. Combining the powerful antifungal properties of Ketoconazole with the proven antibacterial action of Chlorhexidine, this dual-action formula provides fast, effective relief from common skin problems in pets. Designed to cleanse, protect, and soothe, <em>KetoHex</em> is gentle enough for routine use while being tough on harmful microorganisms. Brought to you by the trusted <em>PetField</em> brand, this expertly crafted formula ensures your pet stays healthy and happy.</p>
<h3><strong>Product Indications</strong></h3>
<p><em>KetoHex</em> is recommended for:</p>
<ul>
<li>Addressing fungal and bacterial skin infections in pets.</li>
<li>Managing conditions such as dermatitis and pyoderma.</li>
<li>Reducing skin irritation and supporting the natural healing process.</li>
<li>Providing a clean, healthy coat and long-lasting freshness.</li>
</ul>
<h3><strong>How to Use</strong></h3>
<ol>
<li>Wet your pet’s coat with warm water.</li>
<li>Apply <em>KetoHex</em> shampoo generously, ensuring thorough coverage on the skin and fur.</li>
<li>Massage gently to create a rich lather, focusing on affected areas.</li>
<li>Leave the shampoo on for 5-10 minutes to allow active ingredients to work.</li>
<li>Rinse completely and dry your pet.</li>
<li>Use as directed by your veterinarian or according to the recommended schedule.</li>
</ol>
<h3><strong>Required Considerations</strong></h3>
<ul>
<li>For external use only. Avoid contact with eyes and sensitive areas.</li>
<li>Discontinue use and consult a veterinarian if irritation develops.</li>
<li>Store in a cool, dry place, away from direct heat or sunlight.</li>
<li>Keep out of reach of children and other animals.</li>
</ul>
<h3><strong>Ingredient Actions</strong></h3>
<ul>
<li><strong>Ketoconazole</strong>: A potent antifungal agent that targets yeast and dermatophyte infections, ensuring effective relief from stubborn skin issues.</li>
<li><strong>Chlorhexidine</strong>: A broad-spectrum antibacterial that eliminates harmful bacteria, reduces inflammation, and helps prevent reinfection.</li>
</ul>
<p>&nbsp;</p>
]]></content:encoded>
					
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		<item>
		<title>Gs-441524 25mg &#038; 45mg Tablets, 20mg/ml in 8 ml Vials</title>
		<link>https://formule-art.com/product/gs/</link>
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		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Sun, 24 Dec 2023 20:12:48 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2196</guid>

					<description><![CDATA[<strong>GS-441524 25mg &#38; 45mg Tablets, 20mg/ml in 8 ml Vials</strong>
<div id="gtx-trans" style="position: absolute; left: 90px; top: 45px;">
<div class="gtx-trans-icon"></div>
</div>]]></description>
										<content:encoded><![CDATA[<blockquote>
<h4>Veterinarians can access downloadable material specifically created for recording and monitoring the treatment procedures of individual cats.</h4>
<p style="text-align: left;"><strong><span style="color: #000000;">
</p></blockquote>
<p><i class="fa fa-download my-custom-class " ></i> <a class="button" style="color: #000000;" href="https://formule-art.com/wp-content/uploads/2023/12/Cat-Guards-GS-Monitoring-Material-for-Printing-1.pdf"><b>Click to Download</b>: Cat Guard&#8217;s GS Monitoring Material for Printing</a></span></strong></p>
<h2>GS-441524 25mg &amp; 45mg Tablets, 20mg/ml in 8 ml Vials</h2>
<p><strong>GS-441524</strong>, an antiviral drug, is a nucleoside analog that has shown promise in the treatment of specific viral infections in animals, specifically feline infectious peritonitis (FIP). It is closely related to Remdesivir, which garnered significant attention during the COVID-19 pandemic. The mechanism of action of GS-441524 involves mimicking nucleosides to disrupt the replication process of viruses, thereby impeding the synthesis of viral RNA and hindering the virus&#8217;s ability to replicate. Multiple studies have been conducted on different forms of FIP, and the results consistently demonstrate that GS-441524 is a secure and efficient treatment for FIP. The ideal dosage, determined through research, is 4.0 mg/kg SC q24h for 84-120 days. This medication has been meticulously formulated to minimize any potential local or systemic side effects.</p>
<p>GS-441524 has shown promise specifically in the treatment of Feline Infectious Peritonitis (FIP), a viral disease affecting cats. This drug appears to have advantages over Remdesivir and Molnupiravir in the context of FIP treatment due to several factors:</p>
<p><strong>Efficacy in FIP:</strong> GS-441524 has demonstrated effectiveness in combating FIP, a condition for which there are limited treatment options. Studies have shown positive outcomes in treating FIP symptoms and extending the lifespan of affected cats, particularly when administered via injection.</p>
<p><strong>Specificity:</strong> GS-441524 seems to target the feline coronavirus responsible for FIP more directly compared to Remdesivir and Molnupiravir, which were primarily developed for human viruses like SARS-CoV-2 (COVID-19). This specificity might contribute to its efficacy against FIP in cats.</p>
<p><strong>Administration Route:</strong> GS-441524 has been initially administered via injection, ensuring direct delivery and potentially higher concentrations at the site of infection. However, the development of oral formulations of GS-441524 is an area of ongoing research and could provide more convenient treatment options in the future. The product can be used on cats and dogs, dogs possess a longer intestinal tract adapted for omnivorous diets, enabling them to absorb up to 85% of GS-441524 orally. In contrast, cats, the primary focus of FIP treatment, exhibit a lower absorption rate of approximately 40% compared to dogs when receiving the drug orally. This variance in absorption rates between the two species influences the development of effective oral formulations for FIP treatment.</p>
<p>&nbsp;</p>
<p><strong>Specially Formulated:</strong> Formule Art Crafted GS-441524, with its precise formulation and top-notch active pharmaceutical ingredients, has effectively reduced the occurrence of common adverse effects in Cats. These adverse effects include skin lesions and burns, pain at the injection sites, sores at injection sites, liver issues and anemia, kidney health problems, and drug reactions resembling systemic vasculitis.</p>
<p>&nbsp;</p>
<p>Indications: Feline Infectious Peritonitis (FIP) Treatment (Wet &amp; Dry) &#8211; Ocular FIP symptoms &#8211; Neurological FIP Symptoms &#8211; Relapse Cases</p>
<p>&nbsp;</p>
<p>Feline Infectious Peritonitis (FIP) stands as a complex and challenging disease affecting domestic and wild cats globally. Despite decades of research, FIP remains a significant threat due to its elusive nature, varying clinical presentations, and the absence of a definitive cure. This review aims to encapsulate the multifaceted aspects of FIP, emphasizing its etiology, clinical manifestations, diagnostic challenges, treatment modalities, and current advancements.</p>
<p>FIP is caused by a mutated strain of feline coronavirus (FCoV), primarily affecting kittens and cats under stress or with weakened immune systems. The transition of the benign enteric FCoV to the fatal FIPV (FIP virus) occurs in a fraction of infected cats, leading to the activation of a hyperimmune response and widespread inflammatory damage in multiple organs, notably the abdomen, thorax, kidneys, and central nervous system.</p>
<p>Clinical manifestations of FIP vary widely, presenting as either effusive (wet) or non-effusive (dry) forms. The effusive form is characterized by the accumulation of fluid in body cavities, while the non-effusive form often involves granulomatous lesions in affected organs. These manifestations make diagnosis challenging, relying on a combination of clinical signs, laboratory tests, and histopathological examinations.</p>
<p>Treatment of FIP remains a considerable challenge. Historically, antiviral drugs such as GS-441524 have shown promise in alleviating symptoms and extending lifespan, particularly when administered via injection. However, the transition to oral formulations has garnered attention for its potential convenience, despite concerns regarding absorption rates and achieving therapeutic concentrations.</p>
<p>Recent advancements in FIP research include exploring novel treatment strategies, such as immunomodulatory agents and combination therapies targeting both the virus and the immune response. Additionally, ongoing studies focus on understanding the host-virus interaction, viral mutations, and immune responses to develop more effective treatment options.</p>
<p>In conclusion, FIP continues to pose significant hurdles in veterinary medicine due to its complexity and the absence of a definitive cure. While treatment options have shown promise, they come with challenges related to administration, absorption, and efficacy. Continued research efforts aimed at unraveling the intricacies of FIP pathogenesis and developing targeted therapies are crucial to improve outcomes and enhance the quality of life for affected feline companions.</p>
<p>&nbsp;</p>
<p><strong>How To Use:</strong>  The product can be used under a veterinarian&#8217;s supervision and monitoring.</p>
<p>Veterinarians can access downloadable material specifically created for recording and monitoring the treatment procedures of individual cats.</p>
]]></content:encoded>
					
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		<title>Apocitinib : OCLACITINIB MALEATE 3.6, 5.4, 16 mg Tablets</title>
		<link>https://formule-art.com/product/apocitinib/</link>
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		<dc:creator><![CDATA[adfa1]]></dc:creator>
		<pubDate>Sun, 24 Dec 2023 19:02:43 +0000</pubDate>
				<guid isPermaLink="false">https://formule-art.de/?post_type=product&#038;p=2159</guid>

					<description><![CDATA[<strong>Apocitinib : OCLACITINIB MALEATE 3.6, 5.4, 16 mg Tablets</strong>

<strong>Drug Class: </strong>JAK inhibitor]]></description>
										<content:encoded><![CDATA[<h2>Apocitinib : OCLACITINIB MALEATE 3.6, 5.4, 16 mg Tablets</h2>
<p><strong>Mechanism of action:</strong><br />
While not being classified as an antihistamine, Oclacitinib functions by suppressing the activity of numerous pruritogenic cytokines and pro-inflammatory cytokines, along with cytokines associated with allergic reactions that rely on the enzymatic activity of JAK1 or JAK3. However, it exerts minimal impact on cytokines involved in hematopoiesis that rely on JAK2.</p>
<p>Apocitinib is a veterinary medication that helps alleviate itching and inflammation in dogs. This condition can cause discomfort for our beloved pets, leading to rashes, scratching, and licking. It is commonly prescribed for allergic dermatitis and atopic dermatitis. Apocitinib targets specific enzymes involved in the itching and inflammation process, providing relief for dogs with these conditions. However, it is crucial to follow veterinary guidance and dosage recommendations when administering Apocitinib, as it may have side effects and interactions that require monitoring.<br />
<strong>Indications:</strong> Pruritus management in dogs with allergic dermatitis and control of atopic dermatitis in dogs aged 12 months or older.<br />
<strong>How To Use:</strong> Tablets are suitable for consumption with or without food.</p>
<p><strong>Required Considerations: </strong>It is important to wash your hands promptly after handling them. Ensure that the product is stored at a controlled room temperature, specifically between 20-25 degrees Celsius(68-77F). To prevent accidental overdose, keep the medication out of reach of pets. WARNINGS: Apocitinib should not be administered to dogs under the age of 12 months. Additionally, it should not be used in dogs with severe infections. It is important to note that Apocitinib may heighten the risk of infection, such as demodicosis, and worsen neoplastic conditions.</p>
<p><strong>Pharmacokinetic:</strong></p>
<p>Dogs absorb Oclacitinib maleate quickly and effectively when taken orally, reaching peak plasma concentrations in less than 1 hour. When 0.4-0.6 mg Oclacitinib/kg was given orally to 24 dogs, the maximum concentration in the blood was 324 ng/mL (with 90% confidence limits of 281 and 372 ng/mL), and the area under the plasma concentration-time curve was 1890 ng∙hr/mL (with 90% confidence limits of 1690 and 2110 ng∙hr/mL). The prandial state of the dogs does not affect the absorption rate or extent. The absolute bioavailability of Oclacitinib maleate is 89%. Oclacitinib has low protein binding, with 66.3-69.7% bound in fortified canine plasma at concentrations ranging from 10-1000 ng/mL. The apparent volume of distribution at steady-state is 942 mL/kg body weight (with 95% confidence limits of 870 and 1014 mL/kg). In dogs, Oclacitinib is metabolized into multiple metabolites, and one major oxidative metabolite was found in the plasma and urine. The main clearance route is metabolism, with minor contributions from renal and biliary elimination. Oclacitinib has minimal inhibition on canine cytochrome P450 enzymes, with inhibitory concentrations 50 times greater than the observed concentrations at the recommended dose. The total body clearance of Oclacitinib from plasma is low, with a mean value of 316 mL/h/kg body weight (with 95% confidence limits of 237 and 396 mL/h/kg body weight, or 5.3 mL/min/kg body weight). The terminal elimination half-life after intravenous and oral administration is similar, with mean values of 3.5 hours (with 95% confidence limits of 2.2 and 4.7 hours) and 4.1 hours (with 95% confidence limits of 3.1 and 5.2 hours), respectively.</p>
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